Pub. Date : 2022 May 2
PMID : 35502476
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regorafenib induces the apoptosis of gastrointestinal cancer-associated fibroblasts by inhibiting AKT phosphorylation. | regorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, Western blot results showed that regorafenib down-regulated the expression of B-cell lymphoma-2 (Bcl-2) and concurrently up-regulated the expression of Bcl-2-associated X (Bax), and regorafenib inhibited the phosphorylation pathway of AKT in CAFs. | regorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, our results provide a model in which regorafenib induces CAFs apoptosis by inhibiting the phosphorylation of AKT, and regorafenib affects macrophage infiltration by reducing the proportion of CAFs in tumor tissues. | regorafenib | AKT serine/threonine kinase 1 | Homo sapiens |