Pub. Date : 2022 Apr 29
PMID : 35501151
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An MPTP mouse model was used to further elucidate the mechanism underlying CREB dephosphorylation. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cAMP responsive element binding protein 1 | Mus musculus |
| 2 | Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cAMP responsive element binding protein 1 | Mus musculus |
| 3 | Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cAMP responsive element binding protein 1 | Mus musculus |
| 4 | Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cAMP responsive element binding protein 1 | Mus musculus |
| 5 | Disrupting CREB/HDAC1 interaction restored CREB activity and protected nigral dopaminergic neurons in the MPTP mouse brains. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cAMP responsive element binding protein 1 | Mus musculus |