Title : Corallodiscus flabellata B. L. Burtt extract and isonuomioside A ameliorate Aβ25-35-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway.

Pub. Date : 2022 Jul

PMID : 35489325






2 Functional Relationships(s)
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1 Furthermore, the antagonistic effect of MK-801 (NMDA receptor blocker, 10 microM) in the presence of isA (10 microM) or SDC extract (20 microg/ml) was investigated in Abeta25-35 (20 microM, 24 h)-induced PC-12 and N9 cells to evaluate whether the observed effects elicited by isA and SDC extract were mediated via the NMDAR2B/CamK II/PKG pathway. Dizocilpine Maleate glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus
2 Moreover, MK-801 blocked the effects of isA and SDC extract on apoptosis, ROS levels, and autophagy in Abeta25-35-induced N9 and PC-12 cells, indicating that isA and SDC extract likely exert neuroprotective effects via the NMDAR2B/CamK II/PKG pathway. Dizocilpine Maleate glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus