Title : Increased mTORC2 pathway activation in lymph nodes of iMCD-TAFRO.

Pub. Date : 2022 Jun

PMID : 35488725






1 Functional Relationships(s)
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1 The mTOR inhibitor sirolimus, which preferentially inhibits mTORC1, has led to sustained remission in a small cohort of anti-IL-6-refractory iMCD patients with thrombocytopenia, anasarca, fever, renal dysfunction and organomegaly (iMCD-TAFRO). Sirolimus interleukin 6 Homo sapiens