Title : Losartan Mitigates Oxidative Stress in the Brains of Aged and Inflamed IL10 -/- Mice.

Pub. Date : 2022 Apr 29

PMID : 35486382






3 Functional Relationships(s)
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1 Losartan treatment for four weeks is associated with lower AT1R protein level, Nitrotyrosine, and Tau protein in the frontal cortex of aged IL-10 -/- mice. Losartan angiotensin II, type I receptor-associated protein Mus musculus
2 Our results highlight the impact of Losartan, an AT1R blocker commonly prescribed for treating high blood pressure, on the brain-specific angiotensin system and AT1R-linked downstream effects such as brain oxidative stress damage and Tau burden in a frailty mouse model. Losartan angiotensin II, type I receptor-associated protein Mus musculus
3 Our results highlight the impact of Losartan, an AT1R blocker commonly prescribed for treating high blood pressure, on the brain-specific angiotensin system and AT1R-linked downstream effects such as brain oxidative stress damage and Tau burden in a frailty mouse model. Losartan angiotensin II, type I receptor-associated protein Mus musculus