Title : Overexpression of progranulin increases pathological protein accumulation by suppressing autophagic flux.

Pub. Date : 2022 Jun 30

PMID : 35483222






2 Functional Relationships(s)
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1 Moreover, PGRN overexpression enhanced polyglutamine aggregation and aggregate-prone TDP-43 accumulation, indicating that the suppression of autophagic flux by excessive amounts of PGRN worsens the pathology of neurodegenerative diseases. polyglutamine granulin precursor Homo sapiens
2 Moreover, PGRN overexpression enhanced polyglutamine aggregation and aggregate-prone TDP-43 accumulation, indicating that the suppression of autophagic flux by excessive amounts of PGRN worsens the pathology of neurodegenerative diseases. polyglutamine granulin precursor Homo sapiens