Pub. Date : 2022 Mar-Apr
PMID : 35480532
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rasagiline Pharmacokinetics in CYP1A2 Variant Healthy Smokers & Non-smokers in Different Doses. | rasagiline | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | Objectives: Rasagiline, a drug for Parkinson"s disease is metabolized by CYP1A2 enzyme. | rasagiline | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 3 | The objective of the study was to investigate the influence of cytochrome P450 1A2 variants and smoking status of healthy individuals on the pharmacokinetics of rasagiline. | rasagiline | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 4 | Conclusion: The study concludes that the systemic metabolism of rasagiline is significantly increased in CYP1A2*AA variants while smoking status did not show consistent difference in PK parameters. | rasagiline | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |