Title : Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.

Pub. Date : 2022

PMID : 35479080






2 Functional Relationships(s)
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1 Nicotine partially prevented the IL1beta-induced expression and production of IL6, MMP3, and RANKL in WT osteoblasts. Nicotine interleukin 6 Mus musculus
2 The effect for IL6 and MMP was mediated by alpha7nAchR since nicotine had no effect on Chrna7-/- osteoblasts while the RANKL decrease persisted. Nicotine interleukin 6 Mus musculus