Title : ABCB1 as a potential beneficial target of midostaurin in acute myeloid leukemia.

Pub. Date : 2022 Jun

PMID : 35462331






2 Functional Relationships(s)
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1 Therapeutic outcome of the crucial anthracycline-based induction therapy often can be compromised by a resistant phenotype associated with overexpression of ABCB1 transporters. Anthracyclines ATP binding cassette subfamily B member 1 Homo sapiens
2 In line with these data, midostaurin potentiated proapoptotic processes in ABCB1-overexpressing leukemic cells when combined with anthracyclines. Anthracyclines ATP binding cassette subfamily B member 1 Homo sapiens