Pub. Date : 2022 Apr 14
PMID : 35455747
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of the CFTR modulator combination ELX/TEZ/IVA on CFTR-mediated Cl- and HCO3- secretion was assessed in organoid-derived intestinal epithelial monolayers. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |
| 2 | RESULTS: ELX/TEZ/IVA markedly enhanced CFTR-mediated bicarbonate and chloride transport across intestinal epithelium of both patients. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |
| 3 | CONCLUSIONS: Current measurements in organoid-derived intestinal monolayers can readily be used to monitor CFTR-dependent epithelial Cl- and HCO3- transport. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |