Pub. Date : 2022 Apr 5
PMID : 35455696
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1). | Enalaprilat | carboxylesterase 1 | Homo sapiens |
| 2 | The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1). | Enalaprilat | carboxylesterase 1 | Homo sapiens |
| 3 | Mean peak and trough enalaprilat concentrations, adjusted by clinical variables, were significantly lower in CES1 rs2244613 heterozygotes (by 16.6% and 19.6%) and in CC homozygotes (by 32.7% and 41.4%) vs. the AA genotype. | Enalaprilat | carboxylesterase 1 | Homo sapiens |