Title : A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity.

Pub. Date : 2022 Apr 20

PMID : 35450821






1 Functional Relationships(s)
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1 We demonstrate that induction of such dual-antigen-targeted cell-mediated immune response might provide better protection against variants displaying highly mutated Spike proteins, as infectious viral loads of both Wuhan-like and beta variants were decreased after challenge of ZIP1642 vaccinated hamsters. zip1642 surface glycoprotein Severe acute respiratory syndrome coronavirus 2