Title : NKCC1 Deficiency in Forming Hippocampal Circuits Triggers Neurodevelopmental Disorder: Role of BDNF-TrkB Signalling.

Pub. Date : 2022 Apr 15

PMID : 35448033






2 Functional Relationships(s)
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1 The time-sensitive GABA shift from excitatory to inhibitory is critical in early neural circuits development and depends upon developmentally regulated expression of cation-chloride cotransporters NKCC1 and KCC2. gamma-Aminobutyric Acid solute carrier family 12 member 5 Homo sapiens
2 The high NKCC1/KCC2 expression ratio decreases in early neural development contributing to GABA shift. gamma-Aminobutyric Acid solute carrier family 12 member 5 Homo sapiens