Pub. Date : 2022
PMID : 35444517
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyglutamine Expansion in Huntingtin and Mechanism of DNA Damage Repair Defects in Huntington"s Disease. | polyglutamine | huntingtin | Homo sapiens |
| 2 | Mutations in huntingtin (HTT) gene that lead to polyglutamine repeat expansion at the N-terminal of HTT protein has been shown to disrupt transcription-coupled DNA repair process, a specialized DNA repair process associated with transcription. | polyglutamine | huntingtin | Homo sapiens |
| 3 | Mutations in huntingtin (HTT) gene that lead to polyglutamine repeat expansion at the N-terminal of HTT protein has been shown to disrupt transcription-coupled DNA repair process, a specialized DNA repair process associated with transcription. | polyglutamine | huntingtin | Homo sapiens |
| 4 | Mutations in huntingtin (HTT) gene that lead to polyglutamine repeat expansion at the N-terminal of HTT protein has been shown to disrupt transcription-coupled DNA repair process, a specialized DNA repair process associated with transcription. | polyglutamine | huntingtin | Homo sapiens |
| 5 | Due to the recent progress made in understanding the mechanisms of DNA repair in relation to HD, in this review, we will mainly focus on the mechanisms by which the wild-type huntingtin (HTT) protein helps in DNA repair during transcription, and the how polyglutamine expansions in HTT impedes this process in HD. | polyglutamine | huntingtin | Homo sapiens |