Title : Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages.

Pub. Date : 2022 Apr 19

PMID : 35440074






1 Functional Relationships(s)
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1 Here, we found that DHEA inhibited the NLRP3 inflammasome components expression by blocking inflammatory signals in lipopolysaccharide (LPS)-primed macrophages, and prevented the bacterial toxin nigericin (Nig)-induced NLRP3 inflammasome assembly. Nigericin NLR family pyrin domain containing 3 Homo sapiens