Title : Pharmacogenetics may explain part of the interindividual variability of dobutamine pharmacodynamics in neonates.

Pub. Date : 2022 Apr 18

PMID : 35437830






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1 METHODS: Alleles in the known genetic single nucleotide polymorphisms in beta1 and beta2 adrenoceptor (AR) genes and Gs protein alpha-subunit gene (GNAS) possibly affecting inotropic effect were identified in patients of neonatal dobutamine pharmacokinetic-pharmacodynamic study. Dobutamine adrenoceptor beta 2 Homo sapiens