Pub. Date : 2022 Jul
PMID : 35436742
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All-trans retinoic acid inhibits the osteogenesis of periodontal ligament stem cells by promoting IL-1beta production via NF-kappaB signaling. | Tretinoin | interleukin 1 alpha | Homo sapiens |
| 2 | Levels of interleukin-1beta (IL-1beta) were increased at varied time points after ATRA treatment. | Tretinoin | interleukin 1 alpha | Homo sapiens |
| 3 | The inhibitive influence of ATRA on the osteogenesis of PDLSCs was partially reversed after neutralizing IL-1beta. | Tretinoin | interleukin 1 alpha | Homo sapiens |
| 4 | Taken together, our results demonstrate that ATRA disrupts the osteogenesis and mineralizationof PDLSCs by promoting IL-1beta expression via activating NF-kappaB signaling and NLRP3 inflammasome, which may offer a new method for improving the ATRA-induced disruption of osteoblast differentiation. | Tretinoin | interleukin 1 alpha | Homo sapiens |
| 5 | Taken together, our results demonstrate that ATRA disrupts the osteogenesis and mineralizationof PDLSCs by promoting IL-1beta expression via activating NF-kappaB signaling and NLRP3 inflammasome, which may offer a new method for improving the ATRA-induced disruption of osteoblast differentiation. | Tretinoin | interleukin 1 alpha | Homo sapiens |