Pub. Date : 2022 Mar
PMID : 35434015
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NLRP3 inflammasome activation was Reactive oxygen species (ROS) dependent, and the protein level was regulated when N-acetylcysteine (NAC) and adenosine triphosphate (ATP) were selected as tools for regulating ROS. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | NLRP3 inflammasome activation was Reactive oxygen species (ROS) dependent, and the protein level was regulated when N-acetylcysteine (NAC) and adenosine triphosphate (ATP) were selected as tools for regulating ROS. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | NLRP3 inflammasome activation was Reactive oxygen species (ROS) dependent, and the protein level was regulated when N-acetylcysteine (NAC) and adenosine triphosphate (ATP) were selected as tools for regulating ROS. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | NLRP3 inflammasome activation was sensitive to both ATP-mediated ROS level increases and NAC-mediated ROS inhibition, suggesting that ROS is associated with the activation of NLRP3 inflammasome in necroptosis. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | NLRP3 inflammasome activation was sensitive to both ATP-mediated ROS level increases and NAC-mediated ROS inhibition, suggesting that ROS is associated with the activation of NLRP3 inflammasome in necroptosis. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | NLRP3 inflammasome activation was sensitive to both ATP-mediated ROS level increases and NAC-mediated ROS inhibition, suggesting that ROS is associated with the activation of NLRP3 inflammasome in necroptosis. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 7 | NLRP3 inflammasome activation was sensitive to both ATP-mediated ROS level increases and NAC-mediated ROS inhibition, suggesting that ROS is associated with the activation of NLRP3 inflammasome in necroptosis. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 8 | NLRP3 inflammasome activation was sensitive to both ATP-mediated ROS level increases and NAC-mediated ROS inhibition, suggesting that ROS is associated with the activation of NLRP3 inflammasome in necroptosis. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 9 | These results suggest that Nrf2 regulates NQO1 to attenuate ROS, which negatively regulates NLRP3 inflammasome. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 10 | Conclusions: Nrf2/NQO1 was an inhibitor of ROS-induced NLRP3 inflammasome activation in Q-VD-OPH-induced necroptosis following cerebral I/R injury. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |