Pub. Date : 2022 Mar
PMID : 35415275
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heterodimeric HIF transcription factor activity is regulated post-translationally by selective PHD proline hydroxylation of its HIF1alpha subunit, accelerating HIF1alpha ubiquitination and proteasomal degradation, preventing HIF heterodimer assembly, nuclear accumulation, and activation of its target oxygen homeostasis genes. | Proline | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Heterodimeric HIF transcription factor activity is regulated post-translationally by selective PHD proline hydroxylation of its HIF1alpha subunit, accelerating HIF1alpha ubiquitination and proteasomal degradation, preventing HIF heterodimer assembly, nuclear accumulation, and activation of its target oxygen homeostasis genes. | Proline | hypoxia inducible factor 1 subunit alpha | Homo sapiens |