Title : Loss of PBRM1 alters promoter histone modifications and activates ALDH1A1 to drive renal cell carcinoma.

Pub. Date : 2022 Apr 12

PMID : 35412614






1 Functional Relationships(s)
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1 We show that one such target gene, ALDH1A1, which regulates a key step in retinoic acid biosynthesis, is consistently upregulated with PBRM1 loss in ccRCC cell lines and primary tumors, as well as non-malignant cells. Tretinoin aldehyde dehydrogenase 1 family member A1 Homo sapiens