Pub. Date : 2022 Jun
PMID : 35405615
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Capsaicin ameliorates intermittent high glucose-mediated endothelial senescence via the TRPV1/SIRT1 pathway. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 2 | Capsaicin restored AMPK phosphorylation and IHG-inhibited TRPV1 expression. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 3 | Moreover, TRPV1 silencing suppressed SIRT1 expression and abolished the anti-senescence effects of capsaicin. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 4 | CONCLUSION: Capsaicin elevates SIRT1 levels through TRPV1/(Ca2+)i/CaMKII/AMPK pathway and suppresses IHG-mediated endothelial cell senescence. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |