Pub. Date : 2022 Jul
PMID : 35403328
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Finally, the intracellular reactive oxygen species (ROS) was measured and the ROS inhibitor N-acetyl-L-cysteine (NAC) was used to investigate whether ROS was required for PM2.5-induced NLRP3 inflammasome activation and pyroptosis under ischemic conditions. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Moreover, we observed that PM2.5 exposure increased the production of intracellular ROS following OGD/R, while inhibiting ROS production with NAC partially attenuated PM2.5-induced NLRP3 inflammasome activation and pyroptosis under ischemic conditions. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Moreover, we observed that PM2.5 exposure increased the production of intracellular ROS following OGD/R, while inhibiting ROS production with NAC partially attenuated PM2.5-induced NLRP3 inflammasome activation and pyroptosis under ischemic conditions. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | CONCLUSION: These results suggested that PM2.5 exposure triggered the activation of NLRP3 inflammasome and pyroptosis under ischemic conditions, which may be mediated by increased ROS production after ischemic stroke. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |