Title : A Novel N-Arylpyridone Compound Alleviates the Inflammatory and Fibrotic Reaction of Silicosis by Inhibiting the ASK1-p38 Pathway and Regulating Macrophage Polarization.

Pub. Date : 2022

PMID : 35401236






1 Functional Relationships(s)
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1 In vivo, our results showed that AKEX0011 ameliorated silica-induced imaging lung damages, respiratory dysfunction, reduced the secretion of inflammatory and fibrotic factors (TNF-alpha, IL-1beta, IL-6, TGF-beta, IL-4, and IL-10), and the deposition of fibrosis-related proteins (collagen I, fibronectin, and alpha-SMA), regardless of early or advanced therapy. Silicon Dioxide interleukin 1 alpha Homo sapiens