Title : AZD5153, a Bivalent BRD4 Inhibitor, Suppresses Hepatocarcinogenesis by Altering BRD4 Chromosomal Landscape and Modulating the Transcriptome of HCC Cells.

Pub. Date : 2022

PMID : 35399501






2 Functional Relationships(s)
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1 Interestingly, AZD5153 treatment upregulated NAMPT, whose product is the rate-limiting enzyme for NAD+ synthesis from nicotinamide. AZD5153 nicotinamide phosphoribosyltransferase Mus musculus
2 This may explain why AZD5153 acted in concert with FK866, a potent NAMPT inhibitor, in reducing HCC cell proliferation and clonogenic survival. AZD5153 nicotinamide phosphoribosyltransferase Mus musculus