Pub. Date : 2022 Apr 8
PMID : 35395768
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells. | Hyaluronic Acid | bone morphogenetic protein 2 | Homo sapiens |
| 2 | However, whether BMP2 can regulate the production of hyaluronan in human granulosa cells has never been elucidated. | Hyaluronic Acid | bone morphogenetic protein 2 | Homo sapiens |
| 3 | METHODS: In the present study, we investigated the effect of BMP2 on the production of hyaluronan and the underlying molecular mechanism using both immortalized (SVOG) and primary human granulosa-lutein (hGL) cells. | Hyaluronic Acid | bone morphogenetic protein 2 | Homo sapiens |
| 4 | RESULTS: Our results showed that BMP2 treatment significantly increased the production of hyaluronan by upregulating the expression of hyaluronan synthase 2 (HAS2). | Hyaluronic Acid | bone morphogenetic protein 2 | Homo sapiens |
| 5 | CONCLUSIONS: Our findings provide new insight into the molecular mechanism by which BMP2 promotes the production of hyaluronan in human granulosa cells. | Hyaluronic Acid | bone morphogenetic protein 2 | Homo sapiens |