Title : Rosmarinic acid ameliorates renal interstitial fibrosis by inhibiting the phosphorylated-AKT mediated epithelial-mesenchymal transition in vitro and in vivo.

Pub. Date : 2022 Apr 20

PMID : 35373225






1 Functional Relationships(s)
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1 It was found that RA treatment decreased the expression levels of alpha-smooth muscle actin (alpha-SMA), collagen I, fibronectin, transforming growth factor (TGF)-beta1, vimentin and phosphorylated AKT (p-AKT) while increasing the E-cadherin expression in both UUO kidneys and IS-treated NRK-52E cells. rosmarinic acid transforming growth factor, beta 1 Rattus norvegicus