Title : Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.

Pub. Date : 2022

PMID : 35359876






1 Functional Relationships(s)
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1 DFO alleviated IL-1beta- and erastin-induced cytotoxicity in chondrocytes, abrogated ROS and lipid ROS accumulation and the increase in MDA, improved OA-like changes in chondrocytes, and promoted nuclear factor E2-related factor 2 (Nrf2) antioxidant system activation. Deferoxamine interleukin 1 alpha Mus musculus