Title : Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease.

Pub. Date : 2022 Mar 30

PMID : 35354793






1 Functional Relationships(s)
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1 Adding the autophagy inhibitor 3-methyladenine or chloroquine attenuated the inhibitory effect of Irisin on beta-GP-induced ROS production, NLRP3 inflammasome activation, pyroptosis, and calcification in VSMCs. 3-methyladenine NLR family, pyrin domain containing 3 Mus musculus