Pub. Date : 2022 Mar
PMID : 35347963
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2. | gingerol | alanyl aminopeptidase, membrane | Rattus norvegicus |
| 2 | This study reveals that 6-gingerol can improve insulin sensitivity of adipose tissues in aging rats with glycolipid metabolism disorders, and this effect is presumedly achieved by enhancing the PI3 K/Akt signaling pathway, inhibiting adipose tissue inflammation, increasing APN synthesis, enhancing AdipoR1 expression, and activating its downstream AMPK/PGC-1alpha signaling pathway. | gingerol | alanyl aminopeptidase, membrane | Rattus norvegicus |