Title : Interaction between posaconazole and flucloxacillin in a lung transplant patient: decrease in plasma exposure of posaconazole and possible undertreatment of invasive aspergillosis: case report.

Pub. Date : 2022 Mar 27

PMID : 35346142






1 Functional Relationships(s)
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1 Presumably the underlying mechanism is activation of the pregnane X receptor by flucloxacillin, which can induce cytochrome P450, uridine glucuronosyl transferase (UGT1A4) and P-glycoprotein. Floxacillin nuclear receptor subfamily 1 group I member 2 Homo sapiens