Pub. Date : 2022 May
PMID : 35344809
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modafinil exerts anticonvulsive effects against lithium-pilocarpine-induced status epilepticus in rats: A role for tumor necrosis factor-alpha and nitric oxide signaling. | Modafinil | tumor necrosis factor | Rattus norvegicus |
| 2 | Status epilepticus-induced animals showed significantly higher NO metabolite and TNF-alpha levels in their hippocampal tissues, an effect that was reversed by modafinil (100 mg/kg, i.p.) | Modafinil | tumor necrosis factor | Rattus norvegicus |
| 3 | Administration of NOS inhibitors resulted in excessive NO level reduction but an escalation of TNF-alpha level in modafinil-treated SE-animals. | Modafinil | tumor necrosis factor | Rattus norvegicus |
| 4 | CONCLUSION: Our study revealed anticonvulsive effects of modafinil in the lithium-pilocarpine-induced SE rat model via possible involvement of TNF-alpha and nitrergic pathways. | Modafinil | tumor necrosis factor | Rattus norvegicus |