Title : Hormonal regulation of lipogenic enzymes in chick embryo hepatocytes in culture. Expression of the fatty acid synthase gene is regulated at both translational and pretranslational steps.

Pub. Date : 1986 Nov 15

PMID : 3533937






4 Functional Relationships(s)
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1 Triiodothyronine or insulin caused about a 2.5-fold increase in the relative rate of synthesis of fatty acid synthase. Triiodothyronine fatty acid synthase Gallus gallus
2 Thus, triiodothyronine regulates fatty acid synthase primarily by controlling the amount of its mRNA. Triiodothyronine fatty acid synthase Gallus gallus
3 After the addition of triiodothyronine, fatty acid synthase mRNA accumulated with sigmoidal kinetics, approaching a new steady state about 48 h after the addition of hormone. Triiodothyronine fatty acid synthase Gallus gallus
4 We suggest that the abundances of both fatty acid synthase and malic enzyme mRNAs are regulated by a common triiodothyronine-induced peptide intermediate which has a relatively long half-life. Triiodothyronine fatty acid synthase Gallus gallus