Pub. Date : 2022 Mar 16
PMID : 35293663
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OSI-027 inhibits the tumorigenesis of colon cancer through mediation of c-Myc/FOXO3a/PUMA axis. | OSI 027 | BCL2 binding component 3 | Homo sapiens |
| 2 | In addition, OSI-027 induced the apoptosis of colon cancer cells via upregulation of PUMA. | OSI 027 | BCL2 binding component 3 | Homo sapiens |
| 3 | OSI-027 promoted the expression of PUMA by activation of FOXO3a, and c-Myc knockdown partially increased FOXO3a and PUMA level. | OSI 027 | BCL2 binding component 3 | Homo sapiens |