Title : Physiological and morphological changes in islet B cells following treatment of the guinea pig with alloxan.

Pub. Date : 1986 May

PMID : 3527515






2 Functional Relationships(s)
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1 In summary, after high doses of alloxan were given guinea pigs, serum insulin levels were reduced below control levels within 24 hr; this was associated with changes in body weight which paralleled changes in insulin levels more closely than did levels of blood or urine glucose; the volume density of immunostained B cells initially decreased and then returned to control levels by 72 hr following alloxan injection. Alloxan insulin Cavia porcellus
2 In summary, after high doses of alloxan were given guinea pigs, serum insulin levels were reduced below control levels within 24 hr; this was associated with changes in body weight which paralleled changes in insulin levels more closely than did levels of blood or urine glucose; the volume density of immunostained B cells initially decreased and then returned to control levels by 72 hr following alloxan injection. Alloxan insulin Cavia porcellus