Title : A non-canonical tricarboxylic acid cycle underlies cellular identity.

Pub. Date : 2022 Mar

PMID : 35264789






1 Functional Relationships(s)
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1 Genetic co-essentiality mapping revealed a cluster of genes that is sufficient to compose a biochemical alternative to the canonical TCA cycle, wherein mitochondrially derived citrate exported to the cytoplasm is metabolized by ATP citrate lyase, ultimately regenerating mitochondrial oxaloacetate to complete this non-canonical TCA cycle. Citric Acid ATP citrate lyase Homo sapiens