Title : Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction.

Pub. Date : 2022 Mar 2

PMID : 35236827






1 Functional Relationships(s)
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1 In mechanism, INHBA is an important ligand of TGF-beta signaling and metformin blocked the activation of TGF-beta signaling by targeting INHBA, and then down-regulated the activity of PI3K/Akt pathway, leading to the reduction of cyclinD1 and cell cycle arrest. Metformin cyclin D1 Homo sapiens