Pub. Date : 2022 Mar 2
PMID : 35233582
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of GRP78 in oxidative stress induced by tunicamycin in trabecular meshwork cells. | Tunicamycin | heat shock protein family A (Hsp70) member 5 | Homo sapiens |
| 2 | OBJECTIVE: To clarify the regulatory effect of GRP-78 induced by tunicamycin on endoplasmic reticulum (ER) stress. | Tunicamycin | heat shock protein family A (Hsp70) member 5 | Homo sapiens |
| 3 | Tunicamycin can also increase expression levels of GRP78,VDAC1, ATF4, PERK, eIF2a, and CHOP (p<0.01). | Tunicamycin | heat shock protein family A (Hsp70) member 5 | Homo sapiens |
| 4 | CONCLUSION: Tunicamycin induces oxidative stress in trabecular meshwork cells, and the increase in GRP78 expression can protect the cells during ER stress by regulating eIF2. | Tunicamycin | heat shock protein family A (Hsp70) member 5 | Homo sapiens |