Title : Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.

Pub. Date : 2022 Mar 14

PMID : 35231446






2 Functional Relationships(s)
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1 Structure of the GAS1-SHH-PTCH1 transition state identifies how GAS1 recognizes the SHH palmitate and cholesterol modifications in modular fashion and how it facilitates lipid-dependent SHH handoff to PTCH1. Cholesterol growth arrest specific 1 Homo sapiens
2 Structure of the GAS1-SHH-PTCH1 transition state identifies how GAS1 recognizes the SHH palmitate and cholesterol modifications in modular fashion and how it facilitates lipid-dependent SHH handoff to PTCH1. Cholesterol growth arrest specific 1 Homo sapiens