Pub. Date : 2022 Apr
PMID : 35228068
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PI3K inhibitor 3-MA promotes the antiproliferative activity of esomeprazole in gastric cancer cells by downregulating EGFR via the PI3K/FOXO3a pathway. | Esomeprazole | epidermal growth factor receptor | Homo sapiens |
| 2 | ESO inhibited PI3K/AKT/FOXO3a signaling and EGFR and SKP2 expression concentration-dependent. | Esomeprazole | epidermal growth factor receptor | Homo sapiens |
| 3 | Furthermore, pretreatment with the EGFR inhibitor AG1478 enhanced the antiproliferative activity of ESO in gastric cancer cells. | Esomeprazole | epidermal growth factor receptor | Homo sapiens |
| 4 | In conclusion, our results suggested that the PI3K inhibitor 3-MA promotes the antiproliferative activity of ESO in gastric cancer cells by synergistically downregulating EGFR via the PI3K/FOXO3a pathway. | Esomeprazole | epidermal growth factor receptor | Homo sapiens |