Pub. Date : 2022 Mar 1
PMID : 35227133
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cholesterol crystals activate NLRP3 inflammasomes and promote gallstone formation by increasing mucin secretion. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Experiments in vitro showed that cholesterol crystals promote MUC5AC secretion; they also increase expression of NLRP3, NLR family CARD domain-containing 4 (NLRC4), apoptosis-associated speck-like protein containing caspase recruitment domain (ASC), and cleaved caspase-1 in biliary epithelial cells. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |