Title : ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation.

Pub. Date : 2022 Feb 26

PMID : 35218410






1 Functional Relationships(s)
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1 CCL2, 5, and 7 known as the elements of the senescence-associated secretory phenotype (SASP) which is a secretome including proinflammatory cytokines and chemokines emitted by senescent cells and a representative feature of senescence, were upregulated by H2O2 treatment or Padi2 knockdown. Hydrogen Peroxide C-C motif chemokine ligand 2 Homo sapiens