Title : Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome.

Pub. Date : 2022 Feb 24

PMID : 35200138






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Aggregation-prone model substrates, including Huntingtin exon 1 containing an expanded polyglutamine repeat, aggregate faster under these conditions. polyglutamine huntingtin Homo sapiens