Title : Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.

Pub. Date : 2022 Mar 10

PMID : 35195417






1 Functional Relationships(s)
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1 Bioisosteric H/F or CH2OH/CF2H replacement was introduced in coumarin derivatives previously characterized as dual AChE-MAO B inhibitors to probe the effects on both inhibitory potency and drug-likeness. coumarin acetylcholinesterase (Cartwright blood group) Homo sapiens