Pub. Date : 2022 May
PMID : 35191133
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucosamine suppresses oxidative stress and induces protective autophagy in osteoblasts by blocking the ROS/Akt/mTOR signaling pathway. | Glucosamine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, GlcN decreased the mammalian target of rapamycin (mTOR) and protein kinase B (Akt). | Glucosamine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | However, the Akt activator (SC79) suppressed the autophagy level induced by GlcN in osteoblasts. | Glucosamine | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Consequently, the antioxidant effects of GlcN were mediated, at least in part, by enhancing autophagy through the Akt/mTOR pathway. | Glucosamine | AKT serine/threonine kinase 1 | Homo sapiens |