Title : Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model.

Pub. Date : 2022 Feb 21

PMID : 35188217






2 Functional Relationships(s)
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1 Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model. Lactic Acid solute carrier family 16 member 1 Homo sapiens
2 Inhibition of lactate influx by the monocarboxylate transporter (MCT)-1 inhibitor, AZD3965, reversed the effect of lactate on GAG accumulation and MMP3 expression and further improved NP cell degeneration in the NPD model. Lactic Acid solute carrier family 16 member 1 Homo sapiens