Title : Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects.

Pub. Date : 2022 Feb 19

PMID : 35183254






2 Functional Relationships(s)
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1 Melatonin activated the protein expression of ALP, OCN, and RUNX-2 and inhibited COX-2/NF-kappaB expression. Melatonin mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 CONCLUSIONS: These results suggest that melatonin promotes the proliferation and osteogenic differentiation of DPSCs by regulating COX-2/NF-kappaB and p38/ERK MAPK signaling pathways. Melatonin mitochondrially encoded cytochrome c oxidase II Homo sapiens