Pub. Date : 2022 Apr
PMID : 35178861
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | The anti-inflammatory drug colchicine exerts its effects, in part, via reducing NLRP3 activity, and has been shown to improve several cardiac diseases, including acute coronary syndrome and pericarditis. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Evaluation of components of the NLRP3 inflammasome revealed an increased percentage of apoptosis-associated speck-like protein containing a CARD domain (ASC)-expressing, caspase-1-expressing, and interleukin-1beta-expressing cells in the myocardium and in the spleen of CVB3 + PBS vs. control mice, which was reduced in CVB3 + colchicine compared with CVB3 + PBS mice. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | In both CVB3 FB and HL-1 cells, colchicine down-regulated the NLRP3 inflammasome-related components ASC, caspase-1, and IL-1beta. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | CONCLUSIONS: Colchicine improves LV function in CVB3-induced myocarditis, involving a decrease in cardiac and splenic NLRP3 inflammasome activity, without exacerbation of CVB3 load. | Colchicine | NLR family pyrin domain containing 3 | Homo sapiens |