Title : Aldehyde Dehydrogenase 2 Family Member (ALDH2) Is a Therapeutic Index for Oxaliplatin Response on Colorectal Cancer Therapy with Dysfunction p53.

Pub. Date : 2022

PMID : 35178443






5 Functional Relationships(s)
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1 Aldehyde Dehydrogenase 2 Family Member (ALDH2) Is a Therapeutic Index for Oxaliplatin Response on Colorectal Cancer Therapy with Dysfunction p53. Oxaliplatin tumor protein p53 Homo sapiens
2 Oxaliplatin resistance is a major issue in the treatment of p53 mutant colorectal cancer (CRC). Oxaliplatin tumor protein p53 Homo sapiens
3 In order to figure out the biomarker for CRC patients with mutant p53 access oxaliplatin, a Gene Expression Omnibus dataset (GSE42387) was used to determine differentially expressed genes (DEGs). Oxaliplatin tumor protein p53 Homo sapiens
4 Finally, we found that combined treatment with ALDH2 inhibitor and oxaliplatin will reduce the sensitivity to oxaliplatin in p53 mutant HT29 cells. Oxaliplatin tumor protein p53 Homo sapiens
5 Finally, we found that combined treatment with ALDH2 inhibitor and oxaliplatin will reduce the sensitivity to oxaliplatin in p53 mutant HT29 cells. Oxaliplatin tumor protein p53 Homo sapiens