Title : Investigation of the Anticancer Effect of α-Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2(1H)-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect.

Pub. Date : 2022 Jan 24

PMID : 35164019






2 Functional Relationships(s)
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1 Gene expression of GST-P, PCNA, PDK, and PIK3CA decreased in the DMBA group treated with alpha-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one, whereas PIK3R1 and BAX increased in the DMBA group treated with alpha-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene glutathione S-transferase pi 1 Rattus norvegicus
2 Gene expression of GST-P, PCNA, PDK, and PIK3CA decreased in the DMBA group treated with alpha-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one, whereas PIK3R1 and BAX increased in the DMBA group treated with alpha-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene glutathione S-transferase pi 1 Rattus norvegicus