Title : Synthesis and In Vitro Activity of Novel Melphalan Analogs in Hematological Malignancy Cells.

Pub. Date : 2022 Feb 3

PMID : 35163680






1 Functional Relationships(s)
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1 Melphalan derivatives were evaluated for cytotoxicity (resazurin viability assay), genotoxicity (alkaline comet assay), and their ability to induce apoptosis (Hoechst33342/propidium iodide double staining method; phosphatidylserine translocation; and caspase 3/7, 8, and 9 activity measurements). Melphalan caspase 3 Homo sapiens